What is a key consideration when using ketorolac in the elderly?

When considering the use of ketorolac in the elderly, renal impairment is a key concern. Older adults often have a decreased glomerular filtration rate (GFR), which can lead to reduced clearance of medications that are primarily eliminated through the kidneys, such as ketorolac. This can increase the likelihood of drug accumulation and consequently enhance the risk of adverse effects, particularly renal toxicity, gastrointestinal bleeding, and cardiovascular events.

Because the elderly population may often have comorbidities such as hypertension, diabetes, and other conditions that affect renal function, it is crucial to evaluate their renal status before administering medications like ketorolac. This ensures safe and effective use while minimizing potential complications. Regular monitoring of renal function in this demographic is essential when using nonsteroidal anti-inflammatory drugs (NSAIDs) to avoid serious side effects.