What is a potential side effect of lidocaine administered at high doses?

Lidocaine, particularly when administered at high doses, can lead to central nervous system (CNS) effects such as drowsiness and weakness. This is primarily due to the drug's mechanism as a local anesthetic, which can cause CNS depression if levels exceed therapeutic thresholds. At elevated concentrations, lidocaine may also interfere with neuronal excitability, leading to symptoms such as lethargy, confusion, and ultimately, progression to more serious manifestations like seizures or even coma in extreme cases.

The risk of CNS effects is heightened during high-dose administration, especially in patients with compromised hepatic function or those taking other medications that can alter lidocaine metabolism. Awareness and monitoring for these side effects are crucial in a clinical setting to ensure patient safety and effectiveness of treatment.