What is the primary organ responsible for the metabolism of Aspirin?

The liver is the primary organ responsible for the metabolism of Aspirin. This is largely due to the presence of hepatic enzymes that facilitate the biotransformation of drugs. Aspirin, which is an acetylsalicylic acid, undergoes significant first-pass metabolism in the liver, where it is converted into various metabolites, including salicylic acid, which is responsible for many of its therapeutic effects and side effects.

The liver plays a central role in drug metabolism by carrying out processes such as oxidation, reduction, hydrolysis, and conjugation, which are crucial for the effective clearance of substances from the body. The metabolic pathways in the liver help ensure that the active forms of drugs are available for therapeutic action while also preparing them for eventual excretion, typically via the kidneys. Therefore, recognizing the liver's integral role in drug metabolism is essential for understanding how medications like Aspirin function within the body.