What is the recommended dosage of Nitroglycerin in the treatment of angina?

The recommended dosage of nitroglycerin for the treatment of angina is 0.4 mg administered sublingually (SL). This dosage is effective in rapidly alleviating angina pectoris by causing vasodilation, which decreases myocardial oxygen demand and improves blood flow to the heart.

Nitroglycerin works by relaxing the smooth muscles of blood vessels, thereby alleviating the symptoms of angina caused by decreased coronary blood flow. Administering it sublingually allows for quick absorption into the bloodstream, providing rapid relief during an anginal episode.

While lower or higher dosages exist, they are not typically used as first-line treatments in this context. The 0.4 mg dose has been established as the standard and is widely accepted in clinical guidelines to ensure effectiveness while minimizing potential side effects.