Which class of drugs inhibits the reuptake of norepinephrine and serotonin?

Tricyclic Antidepressants (TCAs) are known for their mechanism of action, which involves the inhibition of the reuptake of norepinephrine and serotonin in the brain. By blocking the transporters responsible for reabsorbing these neurotransmitters back into the presynaptic neuron, TCAs increase the availability of norepinephrine and serotonin in the synaptic cleft. This enhancement of neurotransmitter levels is beneficial in treating various mood disorders, particularly major depressive disorder.

The other classes of medications listed do not perform this dual reuptake inhibition. Selective Serotonin Reuptake Inhibitors specifically target serotonin reuptake, but do not influence norepinephrine levels. Beta-blockers primarily address cardiovascular issues by blocking the effects of epinephrine and norepinephrine on beta-adrenergic receptors, and do not inhibit neurotransmitter reuptake. Calcium Channel Blockers are used to manage conditions like hypertension and do not involve neurotransmitter mechanisms related to mood regulation. Thus, the unique action of TCAs supports their classification as drugs that inhibit the reuptake of both norepinephrine and serotonin.